0102030405
Decarboxy Carnosine (≥98% Purity) Cosmetic Grade
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Product Description
1. Mechanism of Action (MOA)
Decarboxy Carnosine is a novel derivative of carnosine with enhanced stability and bioavailability. Its primary mechanism involves:
Advanced Glycation End-products (AGEs) Inhibition:
Acts as a potent sacrificial substrate for reactive carbonyl species (RCS) like methylglyoxal (MGO).
Directly binds to and neutralizes reactive dicarbonyls, preventing them from cross-linking with collagen and elastin fibers.
Carbonyl Stress Defense:
Protects cellular proteins from glycation-induced damage by quenching lipid peroxidation-derived aldehydes.
Helps maintain extracellular matrix (ECM) integrity and functionality.
Antioxidant Synergy:
Exhibits complementary antioxidant activity, further reducing oxidative stress that contributes to skin aging.
3. Clinical Results
2. In Vitro Efficacy Data
AGEs Inhibition: 85% inhibition of methylglyoxal-induced collagen glycation at 0.1 mM concentration.
Carbonyl Quenching: 3-fold higher reactivity with MGO compared to standard carnosine.
Collagen Protection: 70% reduction in collagen fluorescence (AGEs marker) in glycation models.
Cellular Protection: Significant decrease in ROS production in fibroblast models under carbonyl stress.
3. Clinical Results
Study Design: 12-week, double-blind study on 40 volunteers (35-60 years) using a serum with 2% Decarboxy Carnosine.
Results:
Skin Elasticity: 18% improvement in cutometer measurements.
Wrinkle Reduction: 25% decrease in crow's feet depth by visioanalysis.
Skin Brightness: Significant reduction in yellowing (ITA° increase of 6.2 points).
Subject Satisfaction: 92% reported improved skin firmness and radiance.
Safety
Non-irritating (HRIPT validated), non-sensitizing, suitable for all skin types including sensitive skin.
Compatibility
Stable in pH 5.0-8.0; compatible with most cosmetic ingredients including:
Antioxidants (vitamin C, E) Other anti-aging peptides Hyaluronic acid
Niacinamide
Antioxidants (vitamin C, E) Other anti-aging peptides Hyaluronic acid
Niacinamide
Formulation Tips
Avoid strong oxidizing agents and highly acidic conditions (<pH 4.0).
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Recommended Usage & Dosage
Concentration: 1-3% in final formulations.
Optimal Dose: 2% for clinically proven anti-glycation effects.
Applicable Products:
Anti-aging serums and creams
Brightening formulations
Professional treatments
Preventive aging products
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Enhanced Efficacy
Superior glycation protection compared to traditional carnosine.
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Dual Action
Combats both glycation and oxidative stress.
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Visible Results
Clinically proven to improve elasticity and reduce wrinkles.
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Skin Brightening
Effectively reduces skin yellowing caused by AGEs accumulation.
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Formulation Friendly
Easy to incorporate, water-soluble, and highly stable.
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Science-Backed
Strong mechanistic data supporting its anti-aging benefits.
Storage
Store in a closed container at a dry place at room temperature.
Animal Testing
Not animal tested
Vegan
Does not contain animal-derived components
GMO
No data available